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Rectal cancer

A phase II clinical trial testing a cancer medicine called Nivolumab in patients with locally advanced rectal cancer. The goal is to see if a low dose (40 mg) of this medicine can help shrink the tumor before surgery, reducing the need for chemotherapy and radiation.

Who can joinWomen

Age18+ years

Kind of studyPhase 2: does it work?

What it testsA medicine and nutrition

The full list of who can and cannot join is on the registry. Ask the trial team, or write to us and we will explain it in simple words.

Contact hospital

The registry names this hospital as the trial's main contact. Ask them which hospitals are taking patients.

Tata Memorial Hospital, MumbaiMumbaiDirections ↗

Registry summary (technical)

A Phase II Single-Arm Trial to Evaluate the Efficacy of Low-Dose Nivolumab (40 mg) as Neoadjuvant Treatment in MSI-High Locally Advanced Rectal Cancer (LARgE CLOuD) - (LARgE CLOuD)

Sponsor: Tata Memorial Hospital
CTRI/2025/07/090631 on CTRI, India's trial registry
Source: Clinical Trials Registry – India (CTRI), via WHO ICTRP, data of 12 Oct 2026
Last updated on the registry 14 Sep 2026 · read by us 5 Nov 2026

Need help reaching the trial team? Write to us.

Tell us the city, the type of cancer and the trial number if you have one. We reply in simple words within 3 working days.

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ట్రయల్ టీమ్‌ను సంప్రదించడానికి సహాయం కావాలా? మాకు ఈమెయిల్ చేయండి.

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